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Multiple Choice

The hypothalamus produces _________, which controls the release of ______ by the anterior pituitary gland.

Releasing hormones from the hypothalamus regulate what the anterior pituitary releases by traveling through the hypothalamo-hypophyseal portal system. In this example, the hypothalamus secretes thyrotropin-releasing hormone, which stimulates the anterior pituitary to release thyroid-stimulating hormone. That TSH then acts on the thyroid to promote thyroid hormone production, forming the thyroid axis. The other hypothalamic releasing hormones pair with different pituitary targets—CRH stimulates ACTH, and GHRH stimulates growth hormone—so the specific TRH-TSH pairing best fits the scenario.

Releasing hormones from the hypothalamus regulate what the anterior pituitary releases by traveling through the hypothalamo-hypophyseal portal system. In this example, the hypothalamus secretes thyrotropin-releasing hormone, which stimulates the anterior pituitary to release thyroid-stimulating hormone. That TSH then acts on the thyroid to promote thyroid hormone production, forming the thyroid axis. The other hypothalamic releasing hormones pair with different pituitary targets—CRH stimulates ACTH, and GHRH stimulates growth hormone—so the specific TRH-TSH pairing best fits the scenario.