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Multiple Choice

What is the most common malignant tumor of the testicle?

Seminoma is the most common malignant tumor of the testicle. It arises from germ cells and typically presents in men in their 30s to 40s as a painless testicular mass. Histologically, seminoma shows uniform cells with clear cytoplasm and central nuclei—the classic “fried-egg” appearance—and it tends to be radiosensitive, often with an excellent prognosis after orchiectomy followed by radiotherapy or chemotherapy when needed. Its pattern of spread is through the lymphatic system to retroperitoneal lymph nodes, which guides staging and treatment. Other malignant testicular germ cell tumors exist but are less common or more aggressive. Embryonal carcinoma tends to be more aggressive and less common as a pure form; choriocarcinoma is highly malignant with early hematogenous spread; teratoma can occur in adults but is not as prevalent as seminoma. The combination of being the most frequent and having a relatively favorable response to standard treatment makes seminoma the correct choice.

Seminoma is the most common malignant tumor of the testicle. It arises from germ cells and typically presents in men in their 30s to 40s as a painless testicular mass. Histologically, seminoma shows uniform cells with clear cytoplasm and central nuclei—the classic “fried-egg” appearance—and it tends to be radiosensitive, often with an excellent prognosis after orchiectomy followed by radiotherapy or chemotherapy when needed. Its pattern of spread is through the lymphatic system to retroperitoneal lymph nodes, which guides staging and treatment.

Other malignant testicular germ cell tumors exist but are less common or more aggressive. Embryonal carcinoma tends to be more aggressive and less common as a pure form; choriocarcinoma is highly malignant with early hematogenous spread; teratoma can occur in adults but is not as prevalent as seminoma. The combination of being the most frequent and having a relatively favorable response to standard treatment makes seminoma the correct choice.