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Multiple Choice

Where is BPH most commonly found?

BPH most commonly involves the transitional zone, the portion of the prostate that surrounds the proximal urethra. With aging, hyperplasia of the glandular and stromal tissue in this zone enlarges nodules that encroach on the urethral lumen, producing the classic lower urinary tract symptoms of obstruction. This zonal pattern also explains why cancers are more often found in the peripheral zone rather than where BPH occurs. The central zone is less typically involved in BPH, and the anterior fibromuscular stroma lacks substantial glandular tissue, so it is not a usual site for hyperplasia.

BPH most commonly involves the transitional zone, the portion of the prostate that surrounds the proximal urethra. With aging, hyperplasia of the glandular and stromal tissue in this zone enlarges nodules that encroach on the urethral lumen, producing the classic lower urinary tract symptoms of obstruction. This zonal pattern also explains why cancers are more often found in the peripheral zone rather than where BPH occurs. The central zone is less typically involved in BPH, and the anterior fibromuscular stroma lacks substantial glandular tissue, so it is not a usual site for hyperplasia.