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Multiple Choice

Which gland produces T3 and T4?

T3 and T4 are produced by the thyroid gland. Thyroid follicular cells take up iodine and incorporate it into tyrosine residues on thyroglobulin, forming the hormones in the colloid as thyroglobulin-bound precursors. Upon stimulation by TSH from the pituitary, these hormones are released into the bloodstream. They then regulate metabolic rate, heat production, and development. The hypothalamus and pituitary regulate this process—via TRH and TSH—but they do not themselves produce the thyroid hormones. The parathyroids, in contrast, secrete parathyroid hormone to regulate calcium, not thyroid hormone production.

T3 and T4 are produced by the thyroid gland. Thyroid follicular cells take up iodine and incorporate it into tyrosine residues on thyroglobulin, forming the hormones in the colloid as thyroglobulin-bound precursors. Upon stimulation by TSH from the pituitary, these hormones are released into the bloodstream. They then regulate metabolic rate, heat production, and development. The hypothalamus and pituitary regulate this process—via TRH and TSH—but they do not themselves produce the thyroid hormones. The parathyroids, in contrast, secrete parathyroid hormone to regulate calcium, not thyroid hormone production.